Dry-wet cycles significantly impact the stability of loess slopes. To understand the durability of stabilized-loess slope protection materials under dry-wet cycles, experiments on direct shear, permeability, and microscopic properties were conducted. Macroscopic properties evolution and microscopic structural damage were studied, leading to the establishment of characteristic functions describing the relationship between macroscopic and microscopic properties. Results showed that biopolymer content mitigated mechanical property deterioration in stabilized-loess, with its effectiveness positively correlated to dosage. Biopolymer content also influenced permeability changes, inversely proportional to dosage. Dry-wet cycles led to loess cementation failure, particle damage, and pore enlargement, mitigated by biopolymer which delayed damage and altered pore development. Prediction accuracy of characteristic functions exceeded 95%, highlighting porosity and large pores (>32μm) as significant factors impacting mechanical properties and permeability, respectively.