[Objective] To explore the changes of soil physical and chemical properties and enzyme activities of different vegetation types in desert saline-alkali land in Hexi Corridor and their influencing factors, so as to provide theoretical basis for soil nutrient cycling and regulation mechanism in desert saline-alkali land. [Method] The soil organic carbon, total nitrogen, total phosphorus, urease, alkaline phosphatase and nitrate reductase were measured under four vegetation types : Lycium ruthenicum single community (HH), Lycium ruthenicum and Phragmites australis community (HL), Lycium ruthenicum and Alhagi camelorum community (HT), Lycium ruthenicum and Tamarix chinensis community(HC). Nitrite reductase activity, variance analysis and redundancy analysis were used to evaluate the differences in soil physical and chemical properties and enzyme activities and their influencing factors. [Result] In the four different vegetation types of soil in Hexi, the organic carbon increased with the soil depth, the highest i