To provide the theoretical and technical references for rational irrigation of rice in cadmium (Cd) polluted rice area, effects of intermittent irrigation at different growth stages on yield component and Cd accumulation of double-cropping rice were studied by pot experiment. The results showed that:(1) The total yield of double-cropping rice in the treatment of flooded irrigation in whole growth duration (FWD) was the highest, and that of treatment of intermittent irrigation in whole growth duration (IWD) and intermittent irrigation at full heading to mid-filling stage (IHM) followed, and that of treatment of intermittent irrigation at booting to full heading stage (IBH) decreased significantly. FWD was beneficial to increase the seed setting rate, while IWD and treatment of intermittent irrigation at tillering to booting stage (ITB) was beneficial to increase effective panicles number. (2) Irrigation modes significantly affected the Cd content in all rice organs at maturity stage, in which IWD had a significant improvement effect, while FWD had a decrease effect. Cd content in grains of early and late rice treated with IBH and IHM was significantly lower than that of treatment of intermittent irrigation at others stages. (3) As for the Cd accumulation of aboveground of rice in the whole growth duration, FWD was the lowest, and IWD was the highest. In all treatments of intermittent irrigation, Cd accumulation in aboveground of rice was relatively lower in treatments of IBH and IHM. In conclusion, in order to ensure the yield of double-cropping rice and reduce the Cd content in rice grains, FWD was the best irrigation mode in Cd polluted rice area, while IHM was the optimal irrigation mode under condition of water resource shortage.