The effects of different organic substitution reducing fertilizer patterns on maize (Zea Mays L.) growth and soil fertility were studied,which provided economic and feasible fertilization scheme and theoretical basis for reducing fertilization and increasing benefits in maize production. Five treatments were set up in the field experiments, which were no fertilizer (CK), conventional fertilization (CF), humic acid organic fertilizer + reduction of 10% nitrogen fertilizer + phosphate and potassium fertilizer (HF), fertilizer synergist + reduction of 10% nitrogen fertilizer + phosphate and potassium fertilizer (BN), commercial organic fertilizer + reduction of 10% nitrogen fertilizer + phosphate and potassium fertilizer (OF).The results showed that compared with CF, HF, BN and OF promoted maize growth, increased plant height and stem diameter at different growth stages. Meanwhile, HF, BN and OF effectively improved maize ear traits and yield components,maize yield increased by 11.12%,6.47% and 14.43%,respectively,net income per hectare increased by 217.24 yuan, 564.99 yuan and -506.46 yuan. The above three treatments increased the contents of soil alkaline nitrogen (AN),available phosphorus (AP) and available potassium (AK) in the growth period of maize,and increased fertilizer recovery efficiency (RE), partial factor productivity (PFP) and agronomic use efficiency (AUE). Among them,the recovery efficiency of nitrogen fertilizer significantly increased by 8.15%, 9.34% and 14.08% (P<0.05),respectively, and potassium fertilizer significantly increased by 15.92%, 21.13% and 29.36% (P<0.05),respectively. Therefore,HF and BN treatments could promote maize growth,increase yield and efficiency, improve fertilizer use efficiency and soil fertility, and provide economical and feasible fertilization scheme and theoretical basis for reducing fertilization and increasing benefits in maize production.