In order to investigate the effects of salt and alkali stress on growth and dry matter accumulation of processing tomato, different salt content soils (CK:1.5 g/kg, S1:4 g/kg, S2:7 g/kg and S3:10 g/kg) were prepared by barrel planting test, the growth index, physiological index, dry matter accumulation and yield of processing tomato under saline alkali stress and drip irrigation condition were studied. The results show that the treatment of S1 promoted the growth index, net photosynthetic rate, transpiration rate, stomatal conductance, leaf water use efficiency and chlorophyll content of processing tomato, but there was no significant difference between this treatment and CK (P>0.05). S2 and S3 treatments had a certain degree of inhibition on the above indicators, most of the maximum or minimum values appeared in S3 treatment, however, at the later growth stage, the stomatal limitation values of processing tomato decreased in the high salinity treatments of S2 and S3, which were generally lower than those of S1 and CK treatments (P<0.01), indicating that the decline of photosynthetic capacity of processing tomato under high saline alkali stress at the later growth stage was mainly caused by the stomatal closure of the leaves, and which was caused by high saline alkali stress. S1 treatment increased the yield of processing tomato by 2.1%, while S2 and S3 treatments reduced the growth of processing tomato by 18.7% and 65.4% respectively. The first stage of fruit expansion was a very important period for the growth and development of processing tomato. At this stage, the processing tomato grew rapidly and the accumulation rate of dry matter was accelerated, reaching the maximum value of the whole growth period. The research results could provide theoretical basis for cultivation and management techniques of processing tomato in saline alkali soil of Xinjiang.