The aim of the experiment was to explore the accurate management mode of water and fertilizer supplies for greenhouse cabbage in Hexi Corridor oasis irrigation area. Greenhouse cabbage plot experiments were conducted to analyze the effects of fertilizer amount and irrigation frequency on cabbage growth, yield, quality, nutrients absorption and water and fertilizer use efficiency. Three fertilizer levels (F₁: N 320-P₂O₅ 160-K₂O 210 kg/hm², F₂: N 260-P₂O₅120-K₂O157.5 kg/hm², F₃: N 200- P₂O₅ 80-K₂O 105 kg/hm²) and two drip irrigation frequencies (H₁: 6 days, H₂: 9 days) were set. The results showed that contents of total nitrogen, phosphorus and potassium consistently increased with the increasing of fertilizer in H₁ treatment. The contents of total nitrogen and phosphorus increased at first and then decreased with the increasing of fertilizer application in H₂ treatment, but the content of potassium increased gradually. Under the same irrigation condition, the partial productivity of fertilizer increased with the decreasing of fertilizer amount. Under the same fertilization level, the contents of nitrogen, phosphorus and potassium and the absorption amount per plant in high irrigation frequency treatment were higher than those in low irrigation frequency treatment, but the partial factor productivity was opposite. The leaf height and diameter, biological yield and dry biomass reached the highest value in the treatment of H₂F₁. The leaf ball compactness, ratio of dry and fresh weight, single head weight, economic yield and economic coefficient were the maximum in H₂F₂ treatment, while the center column, midrib and leaf ratio were the minimum in H₂F₃ treatment. The effects of fertilizer amount and irrigation frequency on the quality of cabbage were significant, and the interaction of two factors reached a significant level. The content of nitrate, soluble sugar and vitamin C was the maximum in the treatment of H₁F₁, H₂F₁ and H₂F₂, respectively. The contents and absorption efficiency of total nitrogen and phosphorus were the maximum in H₂F₂ treatment, and the maximum of potassium content and absorption rate were observed in H₂F₁ treatment. With the increasing of fertilizer amount, water use efficiency also increased gradually, and it was significantly higher in H₂F₁ than that in other treatments. Integrated analysis implied that both the fertilizer amount and the irrigation frequency had significant effects on growth, yield, quality, nutrients absorption and water and fertilizer use efficiency of the greenhouse cabbage, and effect of irrigation frequency was greater than that of fertilizer amount. Thus, H₂F₂ treatment (9 days of irrigation frequency, N 260-P₂O₅ 120-K₂O 157.5 kg/hm²) was the best water and fertilizer application combination for getting the best agronomic traits, yield, quality, nutrient absorption and water and fertilizer utilization efficiency of the greenhouse cabbage in Hexi oasis.