Muddy water irrigation is the main feature of irrigation in the Yellow River irrigation area of the Yellow River Basin. The sediment content in muddy water has important impact on soil water infiltration. The muddy water and clean water film hole irrigation experiments were conducted to reveal the infiltration reduction characteristics of bilateral interference under muddy water film hole irrigation. The relationship between infiltration reduction rate of free infiltration under muddy water film hole irrigation compared to clean water and infiltration time, and the relationship between the infiltration reduction rate of bilateral interference under muddy water film hole irrigation compared to free infiltration and infiltration time had been established in this study. Then we proposed a model to reconstruct the infiltration volume of bilateral interference infiltration under film hole irrigation with muddy water by the infiltration volume of free infiltration under clean water film hole irrigation. The results showed that the infiltration reduction volume of free infiltration under muddy water irrigation compared with clean water increased with the increasing of infiltration time, but the increasing degree reduced gradually. The infiltration reduction volume increased linearly at the later stage of infiltration, and the infiltration reduction rate increased rapidly and then decreased slowly with the increasing of infiltration time. It maintained stable at the later stage of infiltration. The infiltration capacity reduced obviously when the intersection infiltration occurred. The infiltration reduction rates of bilateral interference infiltration and one-way intersection infiltration compared with free infiltration were both increased with the increasing of infiltration time. Compared with one-way intersection infiltration, the bilateral interference infiltration also had the effect of reducing infiltration. The change rates of three infiltration curves were decreased with the increasing of time.