The effects of different halophyte species and configurations on reducing agricultural non-point source pollution were studied by constructing a lakeside vegetation buffer zone on the ninth trunk canal shoreside of Wuliangsuhai Lake, Wulate Front Banner, Inner Mongolia. The results showed that the blank buffer zone without plant had no obvious reduction law of TN, TP and COD in runoff and seepage water. The reduction rates of the Phragmites australisbuffer zone, Suaeda glaucabuffer zone, Tamarix ramosissimabuffer zone, Phragmites australis and Suaeda glauca mixed buffer zone increased first and then slowed down with the increasing of the buffer zone width. The reduction effect of pollutants in seepage water was better than that of runoff water. Among them, P. australis had the best reduction effect on TN and TP in runoff and seepage water,with the reduction rates of 53.56%, 79.17% and 62.37%, 83.25%, respectively. S. glauca had the best reduction effect on COD in runoff and seepage water, with the reduction rates of 50.53% and 67.34%, respectively. Through calculation, the optimal width of the four vegetation buffer zones were 19~29 m, among which the width of S. glauca buffer zone was 19 m. Considering comprehensively, the true halophyte S. glauca could be selected as the preferred plant for the reconstruction of theWuliangsuhai Lake salinized lakeside, and the vegetation buffer zone could be expanded and applied in this area.