According to the requirements of organic agricultural production, through field experiment, we studied the effects of organic drip irrigation on the yield, quality of wine grape, as well as the soil chemical and biological properties of vineyard in the alluvial fan area at eastern foot of Helan Mountain in Ningxia. And the way of high-efficiency utilization of water and fertilizer in barren coarse bone gray ash soil developed from parent material of high mountain in semi-arid area was explored. The results showed that the yield and quality of wine grape treated with different amounts of organic drip irrigation were significantly different (p<0.05), and the yield of the treatment of 3.6 t/hm² was the highest, which was 8.29 t/hm². T_4.5 treatment had the heaviest single fruit and the largest fruit grain. Compared with CK, 3.6 t/hm² treatment significantly increased the contents of soluble solids, soluble sugar, total phenols and anthocyanins in wine grape (p<0.05). The analysis of the relationship between wine grape quality index and fertilization treatment showed that 3.6 t/hm² treatment had the highest score. In 0-20 cm, 20-40 cm and 40-60 cm soil layers, soil organic matter, alkali nitrogen, available phosphorus, available potassium and other chemical properties as well as biological indicators such as urease, alkaline phosphatase, invertase, catalase and so on all increased with the increasing of fertilization amount, and 4.5 t/hm² treatment had the maximum value (p<0.05). The results of this study were great importance to the efficient utilization of limited soil and water resources in the ecologically fragile area of the Helan Mountain alluvial fan area in Ningxia, the production of the most high-end organic wine grape and wine, promote the organic combination of soil and water conservation and economic benefits, and the increase of farmers' income and agricultural efficiency.