The effects of rapeseed cake compost (RSC) on Cd availability in soil and its accumulation in different rice tissues were investigated using a pot experiment in this study. In order to provide reference for the safe production of moderately Cd-contaminated fields, RSC was applied to a Cd contaminated paddy soils (Cd=0.72 mg/kg) with different rates of 0, 0.75%, 1.5%, and 3.0% respectively, and then rice plants (Xiangwanxian 12#) were cultivated. The results showed that:(1) The application of RSC resulted in a sharp decrease in the soil TCLP-extractable Cd concentration. Compared with CK treatment, the soil TCLP-extractable Cd concentrations decreased by 45.1%~68.7% after 0.75%~3.0% RSC application. However, the soil TCLP-extractable Cd concentrations in the amended soil gradually increased during the rice growing period. (2) RSC was an effective organic fertilizer for increasing rice yield, but the total Cd concentrations in rice grain were also increased. Compared with CK treatment, when the 0.75%~3.0% RSC was applied, the total Cd concentrations in rice grain were 0.04~0.14 mg/kg, which met the national limit of Cd in food (GB 2762-2012, Cd<0.2 mg/kg). The rice yield was increased by 3.6~4.3 g/pant, 1 620~1 935 kg/hm² approximately. (3) The application of RSC increased Cd transport from root to shoot and significant raised the amount of Cd accumulated in rice plant, especially in the aerial part. In general, in the present study, the application of RSC increased the total Cd concentrations in rice grain. And it still remained at a low level, could meet the safety production of rice in Cd moderately pollution area. However, if RSC was applied to soil with higher Cd pollution level or higher Cd bioavailability, the total Cd concentrations in rice grain might be higher than the national limit of Cd in food. Therefore, we suggested that the application of RSC should be more prudent for the Cd-contaminated fields for the premise of ensuring rice safety production.