The natural rainfall was observed in the runoff plots with 10° slope in red soil region. Five treatments:bare land as control (CK), down slope tillage (DT), hedgerows with down slope tillage (DT+HG), contour ridge tillage (CT) and straw mulch (SM) were designed. The effects of cultivation measures and rainfall intensities on runoff depth, sediment yield and nutrient losses were evaluated. The results showed that the runoff depth and sediment loss were increased with the increasing rainfall intensities during the rainfall events. With the cultivation measures changed from DT to DT+HG, CT and SM, the effectiveness of the cultivation measures on reducing runoff, nitrogen and phosphorus was increased respectively. The average annual runoff reduction (91.77%) of SM was the highest. But the sediment reduction (98.91%) of DT was the highest. The SM, CT and DT+CT measures were effective in preventing soil erosion and nutrient loss caused by the heavy rainfall. Cultivation measures influenced the sediment size distribution. The DT+HG and SM treatments were more effective on trapping coarser particles compared with DT and CT treatments. This study was helpful for selecting the suitable cultivation measures and provided data support for the protection and regulation of soil and water losses and non-point pollution in sloping cropland.