Soil water and nutrient losses have played an important role in the research on the expansion of non-point source pollution, which also involved in soil erosion, hillslope hydrology and environmental management. Based on the simulated rainfall experiments on loess slope with spray-applied fertilizer (NH₄⁺-N,NO₃^--N,PO₄^3--P), the process of infiltration, soil erosion, and the solute transport process of soil water and solute on slope under interval rain events were investigated. The simulated rainfall experiments were carried out for three interval rain events. Specifically, rainfall intensity was designed as 100 mm/h, and the rainfall lasted 60 min, the rainfall interval was 60 min. Results were as follows:(1) The initial soil moisture content under the three rainfall events were different, but the runoff processes were similar, and the runoff rate showed an increasing trend at first and then tended to be stable. (2) For three interval rain events, the accumulation amounts of sediment were 250.91, 100.20 and 79.76 g, respectively, and the amount of accumulated sediment yield in the 1^st rainfall events was more than those of the 2^nd and 3^rd. The curve of sediment rate increased rapidly to the peak and then decreased slowly, and the average sediment yield decreased with the increase of rainfall frequency. (3) The concentrations of NH₄⁺-N, NO₃^--N were changed from high to low and gradually tended to be stable in three rainfalls. Compared with the NH₄⁺-N, NO₃^--N, the concentration of PO₄^3--P increased at the beginning of rainfall, and then lowered and leveled off. (4) The total loss of NH₄⁺-N, NO₃^--N and PO₄^3--P in surface runoff of three rainfall were 535.33 mg, 1 058.18 mg and 400.79 mg, respectively, and NO₃^--N have the most loss and PO₄^3--P have the least. With the increase of rainfall frequency, NH₄⁺-N, NO₃^-N and PO₄^3--P loss decreased gradually under different rainfall times, the loss amount were reduced 19% and 14%, 3% and 62%, 57% and 28.3% than previous rainfalls. The effects of three rain events on yellow soil of loess slope land reveal the interaction of rainfall, surface runoff and soil, and the mechanism of nutrient loss, also provide the scientific basis for control of water and soil erosion.