By using maximum temperature, minimum temperature and mean temperature, sunshine duration, evaporation, precipitation, relative humidity, and average wind speed of 5 weather stations in Irtysh river valley in Xinjiang from 1961 to 2013, the spatial and temporal trends of the temperature in this region were studied through taking the method of climate trending rate, 5 years running mean tread and Inverse distance weighted interpolation method. The main results were as followed: Diurnal temperature range (DTR) generally showed a reducing trend at scales of the year and decade, and except Altay City, the reduction trends of the rest regions in Irtysh river valley were all significant. Variation trends of DTR in each season were inconsistent, but generally showed reducing trend. Maximum and minimum values of annual DTR assumed reducing trend. Annual maximum and minimum temperature assumed increasing trend. Rapid increasing of minimum temperature and slow rising of maximum temperature were the direct causes of DTR decreasing. The average annual DTR was positively correlated with average temperature and average wind speed, and negatively correlated with sunshine duration, precipitation and relative humidity. Main factors affected the valley DTR were the average temperature, precipitation and average wind speed, and the strongest correlation factor was the average temperature, followed by precipitation. Main influence factor affected DTR varied from each station.