In order to better understand the effects of different fertilization methods on black soil region slopes nutrient loss, exploring different fertilization methods on black soil nutrient loss of slope law, this test used indoor artificial simulated rainfall method systematically to study the influence of surface spraying and mixed fertilization on nutrient loss in black slope under five different soil bulk densities. The results showed that: Surface spraying and mixed fertilization on the black soil had no significant effect on slop runoff process, two fertilization methods, runoff intensity changes were basically the same, the cumulative rainfall runoff also increased with duration extended linear growth relationship. Fertilization of NPK concentration changed in runoff, had a very significant impact. Regardless of soil bulk density increased or decreased in the early runoff, solute concentration at the surface spraying process was much higher than the corresponding mixed fertilization processing, surface runoff spraying nitrate, soluble phosphorus and potassium ions initially runoff concentrations corresponded to 2.6～3.2, 2.1～2.6 and 1.7～2.1 times the combined application process. The total amount of nutrient loss from the point of view, under the same conditions nitrate density, soluble phosphorus, potassium loss volume mixed fertilization were 9～11, 7～10 and 3～6 times at the surface spraying conditions. And with the increase of soil bulk density, surface spraying and mixed fertilization and potassium nitrate loss of two fertilization methods gap narrowed, while the gap between the amount of phosphorus ions loss increased. When the soil bulk density was less than 1.2 g/cm3 the power function fit factors in surface spraying was higher than that in mixed fertilization, when the slope soil bulk density was greater than or equal to 1.2 g/cm3, the mixed fertilization fitting coefficient was higher than the surface spraying.