A field plot experiment was carried out to study the effects of different fertilization on yield and quality of lettuce.The results indicated that the yield of lettuce was increased from 19.4% to 66.4% in adding nitrogen,phosphorus,potassium,boron and organic fertilizer on the basis of N15P5K10(CK),and the effects were all in advance of CF treatment.The best yield was obtained in the rapeseed cake treatment.However,only the application of peat and rapeseed cake brought down the content of nitrate in lettuce stem,and the decrease rates were 9.3% and 18.0%,respectively.The content of Vc in lettuce leaf and stem were all increased in different treatments.The highest content of Vc in lettuce leaf was appeared in adding rapeseed cake treatment(16.5%),and the highest content of Vc in lettuce stem was appeared in adding rapeseed cake and peat treatments.The highest content of reductive sugar was appeared in adding potassium fertilizer treatment in lettuce leaf,and the increase rate was 10.0%.The treatment adding phosphorus fertilizer got the highest content of reductive sugar in lettuce stem.The content of EAA(Essential amino acid) was increased in lettuce leaf(except CF treatment),the proportion of Met/Leu by application of boron was higher than other treatments.The best effects on proportion of Met/Leu,sweet amino acid/TAA(Total amino acid) and fresh amino acid/TAA were appeared in adding peat treatment.The highest fertilization profit of lettuce was appeared in applying rapeseed cake.The output/input ratio of applying potassium fertilizer was higher than other treatments.